Vyvanse Headache Causes and How to Avoid It Vyvanse headaches can occur due to factors such as dehydration, dosage adjustments, or sensitivity to stimulants. If you're experiencing headaches after taking Vyvanse, it could be due to the medication's effects on your nervous system. To avoid Vyvanse headaches, make sure to stay hydrated, take your medication as prescribed, and consult with your doctor if your symptoms persist. For those seeking "Vyvanse headache relief" or "how to reduce Vyvanse side effects," it’s important to monitor your response to the medication and make adjustments with your healthcare provider’s guidance.